What is Percocet?
Percocet is a combination of two drugs one is oxycodone, an opioid analgesic and another one is acetaminophen a Non steroidal anti-inflammatory drug (NSAID). Oxycodone acts on central nervous system to relieve moderately severe pain. Where as acetaminophen reduce fever, inflammation and pain.
When will Percocet used or prescribed?
This is prescribed for treating moderately to moderately severe pain for which alternative treatments are inadequate. This drug is dispensed when a fresh prescription by the physician is being produced by the patient because oxycodone belong to the class of narcotic analgesics (NRX) and cause habit forming leading to misuse and abuse.
What is the normal dose?
This combination is available in tables for oral administration. Available formulations are Oxycodone Hydrochloride, USP 2.5, 5, 7.5, 10 mg + Acetaminophen 325 mg for adults. Petrocet should be used whenever the pain is moderately severe and it is best to start as early as possible.
How to use Percocet?
Take this medication by mouth or as directed by your physician. You may take this drug with or without food. If you have nausea, it may help to take this drug with food. Avoid eating grapefruit or drinking grapefruit juice while using this medication. Grapefruit can increase the chance of side effects with this medicine.
How long the Percocet stay in your system?
Percocet produce the action within 1.5 to 3 hrs upon oral administration. 85% of the dose administered is excreted within 24 hr in urine as free and conjugated form.
What are the Side effects associated with Percocet administration?
As percocet contains narcotic analgesic it causes respiratory depression, adrenal insufficiency, and severe hypotension. Liver toxicity, serious skin reactions and hypersensitivity reactions are associated with acetaminophen.
Will Percocet cause Addiction and abuse?
Addiction can occur at the prescribed doses upon drug is misused or abused. Monitoring for signs of addiction and misuse in patients is needed. Risk evaluation and mitigation strategy is used by health care providers for support of patients with pain. Tolerance and physical dependence is being developed upon prolonged usage of the medication by the patients. Physical dependence may lead to withdrawal effects. Dose tapping is required to prevent physical dependence before treatment is stopped completely.
What is the identification test used to detect drug concentrations?
Urine test is very useful to detect the concentrations after one or two day of drug administration Urine testing for opiates may be performed to determine illicit drug use. TLC and GC/MS may be useful for accurate identification.
What are the precautions to be taken while administering PETROCET?
Monoamine oxidase Inhibitors Should Not Be Taken While Taking PETROCET
Drug interactions with oxycodone
Mixed function oxidase (CYP3A4 and CYP2D6) inhibitors such as erythromycin, ketoconozole, ritonavir increase the plasma concentration oxycodone thereby prolonging its effect.
Will Percocet cause Carcinogenicity, Mutagenicity and Infertility
There is no significant evidence of carcinogenic potential and mutagenic potential of Oxycodone in long term studies. Long term usage may reduce the fertility potential in male and female not known whether these effects are reversible.
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Prof. Venkata Kiran Kumar Mandlem is Head Of Department in CMR College of pharmacy Hyderabad . He Completed PhD in Pharmaceutical Sciences from Andhra University . More info about him MV Kiran Linkedin