How Long Does Wellbutrin Stay in Your System ?


What Is Wellbutrin?

Wellbutrin is an antidepressant drug. Bupropion is the generic version of wellbutrin and is prescribed to treat depression, quit smoking and seasonal affective disorder (SAD). It alters the neurotransmitters such as noradrenaline and dopamine in the brain there by affecting the mood behavior. It may also be prescribed as off-label to treat bipolar disorder, ADHD and sexual dysfunction due to SSRI antidepressants. Duration of treatment for major depression disorder may be long but for cessation of smoking and SAD is shorter.

SAD is a type of depression that occurs mainly during the autumn-winter season. It may take 3-4 weeks to show its effect on brain.  Wellbutrin is available as tablets (100mg, 150mg, and 200mg). Consult your physician if your condition doesn’t improve or worsen.

How Long Does Wellbutrin Stay in Your System

How Long Does Wellbutrin Stay in Your body?

The duration of wellbutrin stay in the body is 33-37 hrs long than any other antidepressant. Several factors can influence how long wellbutrin stay in the body.

Factors that affect how long wellbutrin will stay in your system depend on:

  • Genetic conditions
  • Age and sex
  • Weight
  • Metabolic rate
  • Kidney and liver functioning
  • Dosage
  • Duration of time taken
  • Frequency of use
  • Drug interactions


Blood: wellbutrin can be detected in blood for up to 4 – 9 days after it’s taken

Urine: wellbutrin can be detected in urine for 3-4 days after it’s taken

Hair: wellbutrin can be detected in hair for up to 90 days after it’s taken

Saliva: usually wellbutrin cannot be done using this test.


Side Effects of wellbutrin

If you take an overdose of wellbutrin than prescribed, side effects also increases. The severity of the side effects depends on the dosage of wellbutrin you have taken. There is a range of side effects due to overdose of wellbutrin and following are the some of the common side effects.

  • Drymouth
  • Drowsiness
  • Dizziness
  • Headache
  • Nausea
  • vomiting
  • Constipation
  • Joint pain
  • Blurred vision
  • Diarrhea
  • Weight loss

Serious side effects include 

  • Seizures
  • Fainting
  • Skin rashes
  • Muscle pains
  • tachycardia 
  • mood changes
  • weight changes 
  • Ringing in the ears.

Avoid alcohol or illegal usage of drugs which will decrease the efficacy of wellbutrin or may precipitate seizures.

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